Frozen embryo transfers. Elective freezing of embryos and potentially subsequent FETs are now commonly employed for hyper-responders with increased risks of developing ovarian Exclusion criteria were no transfer, gestational carrier, preimplantation genetic testing, frozen oocyte embryo transfer, embryos frozen on different days, day 2/4/7 embryo transferred, and one or Advances in embryo freezing. But why would INTRODUCTION. After genetic testing, all transfers were Frozen Embryo Transfer (FET) Those having a frozen embryo transfer (FET) typically have embryos frozen from a previous IVF cycle or are choosing to have their embryos biopsied for preimplantation genetic testing (PGT). &nbsp The first pregnancy following the transfer of a frozen-thawed human embryo was reported in 1983. Emerging evidence suggests that natural cycle (NC) FETs are associated with improved outcomes, and that providers should consider increasing the utilization of NC FET at the Introduction. Fresh Embryo Transfer: This is when a fertilized embryo is transferred into the woman’s uterus in the same IVF cycle in which the eggs were retrieved and fertilized. During a compassionate transfer, the embryos are implanted back into the uterus of the woman who created the embryo in an IVF procedure at a time in the woman’s cycle when it’s . We aimed to assess maternal and neonatal outcomes in patients having their first FET after a freeze-all cycle versus those having Several studies have compared the outcomes of frozen embryo transfer (FET) and fresh embryo transfer (ET) [7,8,9,10,11,12]. frozen-thawed embryo transfer. 8%, 54. When the patient is ready for transfer, she is given medications to mimic a natural menstrual cycle, and the FET date is coordinated with the cycle to optimize implantation. Optimization of endometrial preparation protocols before frozen embryo transfer is mandatory to further improve pregnancy outcomes. 1% of the children were born following medically assisted reproduction, including 1. When it comes to frozen embryo single-embryo transfer (SET), one big study found that the cumulative sustained implantation rate after up to three consecutive SET procedures is 95. In the HRT cycle, suppression of follicular growth, endometrial proliferation and subsequent secretory transformation is achieved by the timely Frozen embryo transfer (FET) is a crucial component of assisted reproductive technology, particularly in in-vitro fertilization (IVF) cycles. Main outcome parameters were the Over the past decade, the application of frozen-thawed embryo transfer treatment cycles has increased substantially. 7 percent. Traveling? Make sure to keep them with you (do not pack in checked bags due to Deciding Whether A Fresh or Frozen Embryo Transfer Is Best For You. Fresh embryo transfers usually take advantage of the body’s natural cycle to encourage the fertilized egg to implant into the endometrium. xv Mock embryo Our doctors can perform a fresh or a frozen embryo transfer (FET). . The latest annual report Of 550 chromosomally normal frozen embryo transfers, among women 41 – 42 years old, 62. clinics have promoted freezing all embryos in a cycle followed by subsequent FET for all cycles, regardless of patient characteristics . Estradiol valerate at the dose for endometrial preparation was continued until the day of the serum hCG test, which was 10 days after the embryo transfer. FET uses embryos (fertilized eggs) that have been frozen. Live birth rate and multiple live birth rate were compared among groups of Fresh Embryo Transfer: 6 fresh eggs with a fresh embryo transfer is $12,000. Frozen-thawed embryo transfer (FET) has increased dramatically over the past decade as the indications for the procedure have expanded, in part owing to improvements associated with vitrification compared with older slow-freeze methods(). You can have them all frozen for use at a later time, or you can choose to have an embryo transfer right away. Main Outcome Measure(s): The primary outcome was a singleton live birth. The protocols used to prepare the endometrium for embryo transfer vary more than most of us would imagine -- there is truly no standardization, and each clinic you visit might approach this in a different way. FET may provide a more A small, randomized trial comparing fresh-embryo transfer with frozen-embryo transfer after preimplantation genetic screening showed a higher rate of live birth after frozen-embryo transfer. These embryos, your Undergoing IVF can include the process of transferring frozen embryos. Despite this, however, a 2–3% Introduction. 4%, and 54. Methods The clinical data of 1093 infertile patients who underwent frozen-thawed embryo transfer in our center from January 2019 to December 2020 were retrospectively analyzed (control, 418; atosiban, 675). 9% for women 35-37 years old (date not needed). A frozen embryo transfer is a much simpler procedure for patients and endocrinologists. Here's a breakdown of what to expect, some Frozen transfer of embryos can have greater chances of success with women who have endometriosis, polycystic ovarian syndrome, high progesterone at the trigger, or are of Asian or African ancestry. After the successful transfer of the embryo(s) during that IVF cycle, patients have the option of preserving suitable embryos that remain with cryopreservation, or freezing (known as vitrification). The variation depends on why someone wants to do the biopsy and whether they had a baby from the There are an estimated 600,000 frozen embryos in storage in the United States, but less than 15 percent of those embryos are donated to another couple. In fact, higher OHSS risks and pregnancy loss have been linked to higher estradiol levels Background The optimal time at which to perform a frozen-thawed embryo transfer (FET) following a failed in-vitro fertilization-embryo transfer (IVF-ET) attempt remains elusive to most reproductive experts. Patients were grouped according to the number and grade of cleavage-stage embryo or blastocysts transferred. Frozen embryo transfer (FET) cycles have been increasing globally over the last few years due to the advances in vitrification (Cobo et al. Frozen Embryo Transfer. 1 Among women with ovulatory cycles who are undergoing FET, there are at least four distinct strategies for endometrial preparation: The application of frozen-thawed embryo transfer (FET) has significantly increased the live birth rate (LBR) and reduced the incidence of ovarian hyperstimulation syndrome (OHSS), especially in patients with polycystic ovary syndrome (PCOS) []. Remember, every journey to parenthood is unique, and taking the time to prepare both physically and emotionally This study aimed to elucidate the effect of hatching status on in vitro fertilization (IVF) outcomes in frozen–thawed blastocyst transfer cycles. In our clinic vitrification of “spare” embryos after IVF shows excellent “post-thaw survival” and pregnancy success rates after transfer. This is when a healthy embryo is created in a lab outside of the woman’s body and then put back into the uterus Introduction. Outcome Measures. The primary outcome measure was the LBR. Frozen embryo transfer occurs when an embryo is thawed and implanted into a woman’s uterus. Previously cryopreserved embryo(s) are thawed and transferred into the patient’s uterus at the appropriate time in her menstrual cycle. , 2017). Letrozole is rarely used in frozen embryo cycles. The steps involved during a frozen embryo transfer are as follows: Preliminary Consultation: A fertility expert will do a preliminary scan to evaluate your medical condition and then, based on the assessment, they will create a treatment plan to ensure a successful pregnancy Treatment Discussion: The doctor will Embryo transfer is the process of placing an embryo, created through IVF, into the uterus of a woman who is trying to conceive. The embryos are stored at -196° Centigrade (196° below the freezing point of water!) in a radiation-proof lead dewar (container). There was a The landscape of assisted reproductive technology (ART) has seen a significant shift towards frozen-thawed embryo transfers (FET) over fresh transfers, driven by technological advancements and clinical considerations. Limited evidence suggests that the use of long-term treatment with gonadotropin-releasing hormone (GnRH) agonists followed by frozen-thawed embryo transfer (FET) may be the Endometrial Priming Protocols for Frozen Embryo Transfer. However, the question of whether the Freeze Frozen embryo transfer occurred 5 days (approximately 120 hours) after progesterone initiation. During FET, a cryopreserved embryo (or Understand what to expect, success rates, and the differences between a fresh and frozen embryo transfer (FET) cycle. This series is a comprehensive review of the factors that converge to influence embryo transfer success. Some randomized trials suggest that freezing all embryos in a fresh IVF cycle followed by frozen–thawed ET in subsequent cycles might improve pregnancy and live birth rates [7,8,9]. Patient(s): A total of 44,750 women aged 20–35 years undergoing their first lifetime oocyte retrieval and embryo transfer in 2016– 2017, who had R4 embryos cryopreserved. Ideally, embryos reach the blastocyst stage on the fifth day of embryo development (116 ± 2 h after insemination) []; Purpose The aim of this study was to compare the outcomes of three endometrial preparation methods prior to frozen embryo transfer (FET): Natural cycle (NC), modified natural cycle (mNC), and programmed/artificial cycle (AC) protocols. With the advancement of assisted reproductive technologies, many more patients have embryos cryopreserved (frozen) after a fresh IVF stimulation. What is a frozen embryo transfer cycle? A frozen embryo transfer (FET) cycle means thawing one or more embryos (frozen during a previous treatment cycle) and transferring that embryo (or embryos) to the uterus in order to try to establish a pregnancy. By controlling for embryo quality using euploid frozen embryo transfer cycles, we found no difference in pregnancy outcomes in patients with endometriosis compared with patien Transfer of euploid embryos after PGT has been conclusively demonstrated to improve implantation rates and live birth outcomes compared to untested embryo transfer . One of the most important parameters when performing an embryo transfer that guarantees the success of IVF is the condition of the endometrium. Frozen embryo transfer was initiated on the second menstrual cycle after oocyte retrieval, and a single frozen embryo with best morphology score was transferred first. Typically, we recommend transferring only one Purpose of review: Assisted reproductive technology treatment has seen a significant shift from fresh to frozen embryo transfers (FET). The dynamical model controls for inherent fertility Background: In vitro fertilisation (IVF) or intracytoplasmic sperm injection (ICSI) treatments conventionally consist of a fresh embryo transfer, possibly followed by one or more cryopreserved embryo transfers in subsequent cycles. Embryo cryopreservation is widely used in assisted reproduction treatments, and following the first successful conception using frozen embryo transfer (FET) in 1984 (Zeilmaker et al. Note: Conditional effects of gestational age displayed as adjusted relative differences in combined mean fetal weight and birthweight in fresh embryo transfer (fresh ET) and frozen embryo transfer (FET) Frozen embryo transfers are successful, with 68. When undergoing a frozen embryo Learn the steps of a frozen embryo transfer cycle, from monitoring to implantation, and how long it takes. 9% of BENEFITS OF FROZEN EMBRYO TRANSFER. When to consider FET What is a frozen embryo transfer? A frozen embryo transfer (FET) is a cycle where a frozen embryo from a previous fresh IVF cycle is thawed and transferred back into a woman's uterus. 09. Day 6 frozen transfers were Purpose: The purpose of this study is to determine whether intrauterine infusion of autologous platelet-rich plasma (PRP) gel increases endometrial thickness (EMT) and improves the outcomes of frozen-thawed embryo transfer (FET) in women with thin Adenomyosis can lead to infertility and failure of in vitro fertilization. Therefore, the identification and mitigation of factors that influence the live birth rate after frozen embryo transfer is a good way to increase the “take-home-baby” rate of frozen embryo transfer. FET is also considered a healthier implantation process because it allows for a better connection between the placenta and the mother. 5%) underwent a third. This was not always the case, but huge improvements in freezing and storage techniques have closed the gap. 8% after frozen embryo transfer, and 0. Individually, the live birth rate was 64. But rates vary widely based on many factors, including: Both parents’ overall health. Frozen embryo transfer cycles use less medication, and the process is typically far easier and less stressful than undergoing a fresh IVF egg transfer. When can I do an FET cycle? Frozen embryos remain Frozen embryo transfer (FET) is a crucial component of assisted reproductive technology, particularly in in-vitro fertilization (IVF) cycles. The process is often successful. Learn how this procedure is done and the rates of successful pregnancy. 5 weeks from hormone shots to implantation if the embryo is implanted right away, Feinberg says. This study included 938 ET cycles involving single frozen and thawed good‐quality blastocyst (Gardner grade ≥3BB) between August ART increasingly involves frozen embryo transfer (FET). The investigators review the various types of endometrial preparation including the use of the natural, modified natural, stimulated, and programmed cycles. Previously created embryos through IVF are cryopreserved (frozen) and then thawed and transferred into the uterus. During the following developments, frozen embryo transfer has become an important component of assisted reproductive technology (ART), bringing two important contributions to the field: it provides the means At the time of the frozen embryo transfer, the effect of the ovarian stimulation is worn off and therefore a frozen embryo transfer is performed in a more natural uterine environment compared to the fresh cycle (Healy 2010; Kansal Kalra 2011). Frozen Embryo Transfer: In this case, the embryos are frozen post-fertilization and stored for transfer We included 10,060 frozen embryo transfer cycles from January 2015 to March 2020 in reproductive medical center of Ruijin hospital, Shanghai, China. 0%) patients underwent a second transfer and 803 (8. Propensity Frozen embryo transfer. 4% resulted in a live birth. This means you won't have to undergo another cycle of hormone stimulation and an egg collection. Hormone replacement therapy is now used at the discretion of the doctors because it is easy to coordinate the Difference between fresh and frozen Embryo Transfer. It involves the transfer of previously frozen embryos into the The transfer of frozen embryos (FET), known as delayed embryo transfer, consists of using the embryos created in a previous cycle of in vitro fertilisation (IVF) that were frozen at the time through the What is a frozen embryo transfer? During in-vitro fertilization (IVF), your clinician may choose to conduct either a fresh embryo transfer or a frozen embryo transfer (FET). Success rates with frozen embryo transfer cycles are slightly lower than those with fresh embryo transfer cycles. A cryo-stored embryo cycle is shorter and less involved than a stimulated IVF cycle, as we do not need to stimulate the ovaries to Objective: To determine which variables affect most the clinical pregnancy rate with positive fetal heartbeat (CPR FHB+) when frozen embryo transfer (FET) cycles are performed with day 5 (D5) or day 6 (D6) euploid blastocysts. However, advances in embryo freezing techniques have greatly improved embryo viability after thawing. Recent studies provide compelling evidence to an advantage for the IM route of progesterone administration over the vaginal approach. However, an endometrial thickness <6 mm was associated clearly with a dramatic reduction in live birth rates in fresh and frozen embryo transfer cycles. Maheshwari A, Bhattacharya S, Bowler U, Brison D, Child T, Cole C, et al. But for the same PGT testing on a thawed frozen embryo, the success rate is 55-65 percent. Frozen-thawed embryo transfer (FET) has increased dramatically over the past decade as the indications for the procedure have expanded, in part owing to improvements associated with vitrification compared with older slow-freeze methods (). The endometrium is usually checked with an ultrasound to Frozen-thawed embryo transfer (FET) is an integral component of the In vitro fertilization and embryo transfer (IVF-ET) technique. 7 CCRM, another clinic, shows pregnancy rates of 63-70% from transfers of frozen embryos that have been genetically tested and deemed chromosomally normal. This would include 1 fresh embryo transfer, whereas if you have any additional embryos to be frozen, the remaining transfers will be frozen embryo transfers. A frozen embryo transfer usually occurs 6-8 weeks after the embryo is frozen. For a fresh cycle with PGT to identify chromosome number abnormalities, the pregnancy rate is 68 percent. Hormone replacement therapy is now used at the discretion of the doctors because it is easy to coordinate the C’mon little embryo! Let's go! We decided to do a frozen embryo transfer (FET) for a couple of reasons: To allow my body to recover from the egg retrieval (which is a pretty easy procedure for many patients, but not for me) To allow enough time for preimplantation genetic testing (PGT), or embryo testing Embryo transfer is the ultimate step in the in vitro fertilization process and is the culmination of months to years of preparation. 8 percent miscarriage rate following CCS with a frozen transfer compared to 18. The publication of the initial case of frozen-thawed embryo transfer (FET) in 1983 marked a significant milestone (). 2022; 2022 , hoac007 In frozen embryo transfers the inclusion of LPS seems to result in improved outcomes, both in ovulatory and programed cycles. While fresh transfers are undertaken 3 or 5 Background: Initial observational studies and a systematic review published 5 years ago have suggested that obstetric and perinatal outcomes are better in offspring conceived following frozen rather than fresh embryo transfers, with reduced risks of preterm birth, small for gestational age, low birth weight and pre-eclampsia. When looking at the overall picture, the decision between a fresh or frozen embryo transfer seems to come down to personal considerations like maternal health—including ovarian response rate and the uterine environment—expense, as well as other factors. After determining to adopt FET, how far apart does FET need to be performed for optimal clinical outcomes? Sometimes, both scenarios happen — one embryo is transferred, while surplus embryos are frozen for later use. 1% per transfer for the first, second, and third attempts, respectively. In fresh embryo transfer cycles The implementation of cryopreservation-techniques in the IVF laboratory and the improved survival rates of oocytes, cleavage and blastocyst stage embryos have led to a significant increase in the number of frozen-thawed embryo transfer cycles (FET). This procedure is much like a pap smear, does not require any anesthesia, and is usually painless. In most cases, the procedure is painless and does not require anesthesia. There are several reasons to strongly consider freezing your embryos including to minimize the risk of OHSS or to be able to screen the embryos with PGT-A testing. The patients who don’t accept this opt undergo fresh embryo transfer (fresh ET arm). FET facilitates elective single-embryo transfer, reduces ovarian hyperstimulation syndrome, optimizes endometrial receptivity, allows time for preimplantation genetics testing, and facilitates Frozen–thawed embryo transfer (FET) is a widely accepted procedure used for the storage and transfer of excess embryos produced in fresh in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. By understanding what FET entails and how to prepare for it, you can approach the process with confidence and optimism. However, both fresh and frozen embryo transfers are now over 3 decades old and the data is reassuring. In frozen embryo transfers, estrogen Of the 3,718 index frozen embryo transfers in this cohort, 1,197 (32. frozen embryo transfer. A frozen embryo transfer is just one way we can help improve your chances of building a family. Undoubtedly, estradiol (E 2) coordinately interacts with progesterone and plays an important role in The effect of the luteinizing hormone (LH) elevation before the human chorionic gonadotropin (hCG) trigger in ovulatory frozen-thawed embryo transfer (Ovu-FET) cycles has not been determined. Recent findings: While the artificial-FET cycle provides The process of implantation is characterized by a complex cross-talk between the endometrium and the blastocyst, with the endometrium only being receptive to implantation during a transient window of implantation of approximately 2–3 days during the midsecretory phase. Endometrial receptivity in the FET cycle can be achieved through a hormonal replacement cycle or a natural cycle, and the preparation approach has important implications on the pregnancy itself. Patients with progesterone level below 10 ng/mL on the day of embryo transfer are randomised into However, with the exception of age, the factors that affect the outcomes of frozen embryo transfer are still unclear. Understanding the pros and What to Expect After Your Frozen Embryo Transfer. You might wish to use your frozen embryos if: Success Rates: Fresh vs. A soft catheter is guided into the cervix by ultrasound. Along with the advances in embryo cryopreservation techniques, the optimization of endometrial receptivity has resulted in outcomes for FER that are similar to fresh embryo transfer. 17 Efficient and safe embryo vitrification techniques have contributed to a marked increase in frozen embryo transfer (FET) cycles worldwide during the last decade [1, 2]. A total of 1440 FET cycles were enrolled in this retrospective study, of which 1080 patients received conventional ET and 360 patients received sequential ET. 7% after artificial insemination. Findings In this cohort study of 2433 women who received IVF treatment, a lower likelihood of achieving live birth was observed among women The recent advent of embryo vitrification and its remarkable efficacy has focused interest on the quality of hormone administration for priming frozen embryo transfers (FETs). The use of frozen embryo transfers in IVF treatment Fresh embryo transfers occur within three to five days of the egg retrieval (in which mature eggs are collected from the ovaries), whereas frozen embryo transfers are done with embryos that were Frozen Embryo Transfer is a remarkable option that offers hope to many couples struggling with infertility. Although it is tempting to shift Purpose To evaluate the effects of atosiban on clinical outcomes in patients undergoing frozen-thawed embryo transfer. There In cycles with a fresh embryo transfer, live birth rates increase significantly until an endometrial thickness of 10–12 mm, while in FET cycles live birth rates plateau after 7–10 mm. 1%, respectively. , 1984). Products available for progesterone administration have only been tested in fresh assisted reproduction technologies (ARTs) and not in FET. NatPro will compare the proportion of preeclampsia between two commonly used The Embryo Transfer Day Milestone. Freeze-all embryo protocols followed by elective frozen-embryo transfer constitute an effective method for the prevention of ovarian hyperstimulation syndrome (OHSS), as a recent Cochrane review by Zaat and co Study question: How common is bleeding in early pregnancy after Hormone Replacement Therapy (HRT) Frozen Embryo Transfer (FET) and does bleeding affect the reproductive outcome? Summary answer: A total of 47% of HRT-FET patients experience bleeding before the eighth week of gestation, however, bleeding does not affect the Frozen embryo transfer (FET) was carried out 6 days after the start of the LPS. From 2010 to 2014, the Embryos can be either "fresh" from fertilized egg cells of the same menstrual cycle, or "frozen", that is they have been generated in a preceding cycle and undergone embryo cryopreservation, and are thawed just prior to the transfer, which is then termed "frozen embryo transfer" (FET). Materials and methods A retrospective study from a university-based fertility clinic during the years 2008–2021. Frozen Embryo Transfer (FET) is a technique used in fertility treatments. To prepare for the embryo implantation, the prospective mother may receive estrogen pills or injections to build up the lining of the uterus, and then progesterone A frozen embryo transfer (FET) cycle is a process to help you become pregnant. It can be done using a fresh embryo or a frozen embryo, and fortunately, both are equally safe and effective. The recent study by Pirtea et al. demonstrated that optimal clinical and ongoing pregnancy rates after in vitro fertilization occurred with endometrial thickness of ≥8 mm at the end of the estrogen phase in more than 24,000 fresh embryo transfer cycles and ≥7 mm in more than 20,000 frozen-thawed embryo transfer (FET) cycles. More recent Introduction. 8 It has also been shown that not all doctors are equally A frozen embryo transfer is a cycle where embryos that came from a prior in vitro fertilization cycle are thawed and transferred back into the woman’s uterus. The current study aimed to investigate the impact of transferred blastocyst Frozen Embryo Transfer (FET) has been shown to increase implantation rates and improve obstetrical outcomes. These embryos could be from a previous IVF cycle, leftover embryos from a successful cycle, or intentionally frozen for future use. Freeze-all policy: fresh vs. Sometimes, you might develop symptoms that indicate you’re in the very early stages of pregnancy. 91 to 1. Embryo quality is a key factor affecting assisted reproductive technology (ART) Frozen embryo transfers are characterized by impaired pregnancy outcome and increased incidence of pregnancy loss as compared with fresh IVF/ICSI embryo transfers. However, in both fresh and frozen ETs, a higher serum progesterone does With frozen embryo transfer, it’s crucial that the timing of transfer occur when a woman’s endometrium is receptive, meaning an embryo can implant. However, the search for the best protocol to prepare endometrium in such cycles is still ongoing. A small amount of fluid inside the catheter helps the embryos to be released. Over a third of the IVF cycles in the UK are Frozen-thawed Embryo Transfers (FETs). This is a more common practice for logistical reasons and because this method is more likely to result in a live birth. 1 Among women with ovulatory cycles who are undergoing FET, there are at least four distinct strategies for endometrial preparation: A total of 174 frozen embryo transfer cycles were performed on 128 patients in the endometriosis group, and a total of 522 frozen embryo transfer cycles were performed on 497 patients in the control group. A frozen embryo transfer (FET) is when an embryo created from a previous in vitro fertilization (IVF) cycle or donor egg cycle is thawed and transferred into the uterus with the goal to achieve a pregnancy. In addition, frozen cycles, versus fresh transfer cycles, show higher birth weight deliveries and Such favorable outcomes may be partly due to the fact that frozen embryo transfers make it possible to wait until the ovary has recovered from the ovarian stimulation and the exposed endometrial lining has shed, thus enabling a “fresh start” for both. Success rates of fresh and frozen embryo transfer cycles are now comparable []. Hormone-replaced frozen embryo transfer cycles were defined by the treatment of oral E2 daily until the E2 level was >150 pg/mL and the endometrium measured a goal of ≥7 mm, followed by progesterone, 50–75 mg either intramuscularly in oil or as a vaginal suppository (most of the patients received intramuscular progesterone, with less A Frozen Embryo Transfer (FET) involves thawing your embryos frozen in a previous IVF cycle. Endometrial preparation is a critical step in both the natural and artificial frozen embryo transfer (FET) cycle because the development of the endometrium must be synchronized with the embryo transfer for successful implantation 1. Typically has higher success rates compared to frozen embryo transfer. The rate of oocyte retrieval did not significantly differ between the two groups. They highlight that the key difference between protocols is whether The use of frozen-thawed embryo transfer (FET) has increased over the past decade with improvements in technology and increasing live birth rates. Some even advocate freeze all as the preferred treatment protocol []. 003. Of the 3,718 index frozen embryo transfers in this cohort, 1,197 (32. Frozen transfers also present several advantages for our patients. As the embryos already exist, this cycle does not involve stimulation of your ovaries or egg collection. A patient preparing for an FET has blood tests and ultrasound monitoring in order for the physician to identify the optimal time in the patient's cycle to transfer the The Frozen Embryo Transfer procedure is simple. 5 percent in the fresh transfer group. Frozen embryo transfers can occur years after egg retrieval and fertilization. Moreover, a Whether you are doing a fresh embryo transfer or a frozen embryo transfer, you’ll likely be on progesterone and other supportive medications, so make sure you have enough of them and that you follow directions from your clinic on how to take them. Delayed childbearing leads to increased assisted reproductive technology use by women of advanced maternal age (AMA). , 2020; Mackens et al. The objective of this The Live Birth Rate (LBR) after day 5 (D5) blastocyst transfer is significantly higher than that with D6 embryos in both fresh and frozen-vitrified embryo transfer cycles, according to the most recently published meta-analyses. Pregnancy success rates with Frozen Embryo Transfer. Frozen–thawed embryo transfer (FET) cycles performed at a single fertility center between 2016 and 2021 were retrospectively assessed. In frozen embryo transfers, low‐quality evidence showed that clinical pregnancy rates may be improved in a stimulated cycle compared to a programmed one, and we are uncertain of the effect when comparing a programmed cycle to a natural cycle. Improvements in vitrification now make frozen embryo transfer a viable alternative to fresh embryo transfer. Fresh vs. The “freeze-all” strategy, which involves the freezing of all of the embryos in a fresh cycle and subsequent frozen-thawed embryo transfer (FET), To explore the effect of sequential embryo transfer (ET) on the pregnancy outcome of frozen-thawed embryo transfer (FET) cycle and the indications of sequential transfer. 5 percent as compared to women using fresh embryos with a live birth rate of 53. We may recommend FET if you have preserved embryos and wish to get pregnant again, or if you had an unsuccessful IVF The newer vitrification method for IVF embryo freezing is becoming a much more widely used technology. Both fresh and frozen embryo transfers start with the same basic process of ovulation stimulation, monitoring, and egg retrieval. Laboratory and freezing techniques have significantly improved, so FET has a comparable live birth rate with fresh transfers [9], [20], [42], [48], [54] and many women use their frozen embryos instead of undergoing In a frozen embryo transfer (FET) cycle, the endometrium should be developed optimally before embryo transfer. It involves thawing and then transferring the embryo into a woman’s uterus for hopeful pregnancy. The present evidence is deficient for the trade-offs between the pros and cons of single blastocyst transfer (SBT) versus double blastocyst transfer (DBT) in frozen-thawed embryo transfer cycles for women in advanced reproductive age, especially in the second cycle. Embryos are transferred to the uterus through a catheter. The two main endometrial priming protocols for FET are HRT and natural cycle (NC); less commonly, mild-OS is employed (). At the heart of the process is the frozen embryo transfer cycle. In all, 3. First, a speculum is inserted into your vagina. The timing of embryo transfer, including frozen embryo transfer, To evaluate the outcomes of embryo transfer (ET) and to identify the parameters influencing pregnancy outcomes. Although the Frozen embryo transfers. The indications for FET are broad and need to be considered in the context of how ART is evolving. Moreover, some centers have Key Points. Hormone replacement therapy and the natural cycle are two popular methods for preparing the endometrium. For embryo implantation to take place, i. It is unclear whether fresh or frozen embryo transfer (FET) is the better option. 09 (0. A fresh embryo transfer is one that occurs soon after egg retrieval. A frozen embryo transfer cycle can be conducted any time In a frozen embryo transfer, the embryo is frozen after fertilization and can be created some time before placement into the uterus, potentially even years before. Intervention(s): Fresh elective single embryo transfer and frozen elective single embryo transfer. Frozen embryo transfer success rates have surpassed fresh embryo transfer success lately due to advances in freezing techniques Fresh embryo transfer versus frozen embryo transfer in in vitro fertilization cycles: a systematic review and meta-analysis. In a nutshell, the frozen embryo transfer (FET) cycle entails embryo freezing from a previous IVF cycle, which includes the egg retrieval process, and transferring the frozen embryos to the uterus in an attempt to establish a pregnancy. Frozen embryo transfer: The success rate for frozen embryo transfer also varies by age, with the highest success rates in women under 35 years old, and success rates decline with age. The Centers for Disease Control and Prevention reported that FET comprised 81% of all embryo transfers in the USA in 2020 ( Centers for Disease Control and The eggs are then fertilized and embryos are created in the laboratory. A frozen embryo transfer cycle can be planned as soon as a month after the embryos were created or several years later. During the FET cycle, your embryos are thawed and placed into your uterus. In recent years, given the favorable efficacy and safety of vitrification [ Citation 1 ], the number of FET cycles has been progressively increasing and has exceeded that of fresh embryo transfer cycles in A frozen embryo transfer takes up to 30 minutes to complete. Expand all Collapse all. Success rates can vary depending on various factors, including the woman’s age, the quality of embryos, and the specific circumstances of each case. What is a Frozen embryo transfer cycle (Cryo Cycle)? Following an IVF cycle, there are sometimes one or more good quality embryos which can be frozen and kept in storage for future use. xiv In addition, some clinics may perform a “mock embryo transfer” in advance of embryo transfer to help ensure the procedure will run smoothly. The embryos are placed in a small amount The higher singleton birth weight observed in the frozen embryo transfer cohort is consistent with previous literature , including the aforementioned RCT . Next, the catheter containing the embryos is inserted into your uterus. Some programs have low pregnancy and live birth from their frozen embryo transfer cycles while other IVF programs have live birth rates of over 50% per transfer procedure in women under 35 This fact sheet explains what is involved in the frozen embryo transfer process. The use of frozen embryo transfer cycles has exponentially increased in the last few years. Both estrogen and progesterone were continued until a negative pregnancy test result or until 10 weeks of pregnancy. This is almost the coldest natural temperature known to man. With a fresh embryo transfer, the embryo transfer is performed usually either three or five days after the retrieval. Frozen embryo transfer success rates depend on several factors such as the age of the woman, duration of infertility, quality of the embryos frozen, the day of freezing (day 3 or 5), endometrial thickness, etc. With either a fresh or frozen transfer the endometrium or lining of the uterus needs to be prepared so that the embryo can more easily implant. Thanks to the advances in cryopreservation techniques, frozen embryo transfers have become quite successful in recent years. Success rates for frozen embryo transfer after PGT. Even with FET cycles there are opportunities to minimize medications with a more natural Objective To determine which variables affect most the clinical pregnancy rate with positive fetal heartbeat (CPR FHB+) when frozen embryo transfer (FET) cycles are performed with day 5 (D5) or day 6 (D6) euploid blastocysts. 2012. With advances in cryopreservation (freezing) technology, the second option has become more common at Texas Fertility Center (TFC). The catheter and speculum are then removed and the procedure is complete. When it comes to embryo transfers, there are two types, fresh or frozen—with the biggest difference being around timing. Fertil Steril. A frozen embryo transfer (FET) is a cycle in which the frozen embryos made during the IVF process are thawed and are then transferred back into uterus. e. With the development of in vitro fertilization (IVF) techniques over the past decades, clinicians are constantly seeking ways to optimize IVF outcomes and minimize the treatment risks []. Assisted reproductive technology treatments have seen a significant shift in embryo transfer strategy from fresh embryo transfer to frozen embryo transfer (FET) cycles in recent years. If pregnancy was achieved, estradiol valerate and MVP were stopped at 10 weeks of amenorrhea if < 45 Children born via frozen embryo transfer have similar metabolic profiles to those born via fresh embryo transfer, according to a study published June 6 in the open-access journal PLOS Medicine by Advancements in vitrification techniques, along with an increase in nonelective and elective freeze-all cycles, have led to a significant global rise in frozen embryo transfer (FET) cycles over the last decade. Patients undergoing frozen embryo transfers with blastocyst-stage or cleavage-stage embryos and who satisfy the inclusion and exclusion criteria provide blood samples for progesterone measurement on the day of embryo transfer. What is a frozen embryo transfer? During in vitro fertilization (IVF), embryos that were made following the egg retrieval process can be frozen for later use, known as cryopreservation. Results and conclusions: The pregnancy (positive hCG) and clinical pregnancy rates were 25. This procedure can involve either fresh or frozen embryos. Frozen Embryo Transfer (FET) is becoming standard practice in the In Vitro Fertilization (IVF) industry these If fertility issues have prevented you from having children, consider UW Health's Generations team of experts. The key difference between fresh and frozen embryo transfers lies in the timing of embryo transfer. The use of frozen embryo transfer (FET) in in-vitro fertilisation (IVF) has significantly surged over the past 20 years, now surpassing fresh embryo transfers in terms of cycle numbers worldwide. A fresh embryo transfer requires a mock cycle to be completed. Frozen-thawed embryo transfer (FET) has become a promising approach in assisted reproductive technique cycles in recent years due to cryopreservation technique improvements [1]. Over the past decade, the application of frozen-thawed embryo transfer treatment cycles has increased substantially. The use of frozen embryo transfer cycles (FET) has progressively increased, and its proportion in the USA has doubled from 16 in 2007 to 32. Source: 2007-2017 SART data and CCRM Network internal data 2007-2020. The results for the per-cycle probability of live birth parameter of the dynamical model are not directly comparable to the RRs. The ovulation induction regimen, programmed regimen, and natural regimen are the three Fresh vs. Methods This is a single-center retrospective cohort study of 830 frozen-embryo-transfer cycles performed at a German university hospital from January 2012 to December 2016. Once your doctor has determined that you are ready for the frozen embryo transfer process, your doctor will transfer the embryo(s) into your uterus. Frozen-thawed embryo transfer (FET), as one of the most important related technologies of in vitro fertilization (IVF) and embryo transfer, has been widely used currently, especially after the consistent increasing number of frozen embryos and awareness of ovarian hyper-stimulation syndrome. Over the past four decades, the utilization of embryo freezing has steadily increased in China, Europe, and the United States, with frozen cycles accounting for over 40% of total cycles (). For implantation to occur, the endometrium needs to be in a receptive state that closely matches the developmental stage of the embryo. [Google Scholar] Roque M, Valle M, Guimarães F, Sampaio M, Geber S. Our fertility and laboratory experts use the most advanced method of cryopreservation called vitrification, whereby embryos are frozen very quickly. In cases where fresh embryo transfers fail or in cases where fresh embryos fail to transfer for various reasons, patients choose FET. Design and method A single center retrospective study was performed from March 2017 till February 2021 including all Study question: Is IVF with frozen-thawed blastocyst transfer (freeze-all strategy) more effective than IVF with fresh and frozen-thawed blastocyst transfer (conventional strategy)? Summary answer: The freeze-all strategy was inferior to the conventional strategy in terms of cumulative ongoing pregnancy rate per woman. However, recent studies suggest that frozen embryo transfers may have comparable, if not higher, success rates compared to fresh Keep reading to learn how fresh and frozen embryo transfers differ, including the advantages and disadvantages of each method. Additionally, a frozen transfer is safer in ovarian hyperstimulation syndrome (OHSS) vulnerable patients. Pro: Uterine lining may be more receptive to embryo implantation. Increasing live birth rates resulting from improvements in technology, National data from the Australia and New Zealand Assisted Reproduction Database showing the use of vitrification of Day 5/6 embryos during the period 2009–2013 and the comparison of live birth rates after fresh and frozen-thawed embryo transfer during the same time period. The advent and improvement in vitrification protocols has led to high rates of embryo survival after the thawing process, and at least the same clinical results for frozen-thawed embryo transfer (FET) as for fresh embryo transfer (ET) (Nagy et al. Due to initial data that suggested improved pregnancy rates, placentation, and possibly even improved fetal outcomes with frozen embryo transfer (FET) compared with fresh embryo transfer, some U. You should meet with the doctor or nurse prior to the procedure to discuss the quality of your embryos and how many of those embryos should be placed back into your uterus. In a frozen embryo transfer cycle, the embryo has been previously created, sometimes even years earlier, and then will be placed into the uterus. The time of maximum uterine receptivity is from post-ovulatory days 6-10 (cycle A frozen embryo transfer (FET) is when an embryo created from a previous in vitro fertilization (IVF) cycle or donor egg cycle is thawed and transferred into the uterus with the goal to achieve a pregnancy. 31) 1892 (4 RCTs) ⊕⊕⊕⊝ MODERATE 1: Ovarian hyperstimulation syndrome per cycle with ovarian hyperstimulation: 70 per 1000: Understanding why euploid embryos fail to implant has long been a frustration to patients and providers alike. Methods: We reviewed the outcome of 1242 frozen embryo transfers with respect to the age of the woman, the method of fertilization, embryo quality before and after freezing and the number of embryos transferred. While everyone’s experience will be unique, it is important to be aware of the common physical sensations, emotional fluctuations, restrictions, and precautions during the post-FET period. Each additional egg is $2,000 per egg. doi: 10. Frozen embryo transfer was for the first time successfully accomplished 20 years ago (Zeilmaker et al. However, in both fresh and frozen ETs, a higher serum progesterone does These days, frozen embryo transfers have a 15% higher pregnancy rate. This procedure is known as a Frozen Embryo Transfer (FET) whereby the frozen embryo will be placed back in the uterus at the right time of the month. Reasons to consider a frozen embryo transfer Risk with frozen embryo transfers only: Live birth rate cumulatively for all embryo stages of transfer: 579 per 1000: 600 per 1000 (556 to 643) OR 1. Much like a fresh embryo transfer, the patient must go through IVF to collect as many mature eggs as possible. In this case, your embryos were most likely frozen five, six, or in some cases, seven days after egg The two-week wait between an embryo transfer and taking a pregnancy test can be very tense. Physicians often delay the introduction of FET due to concerns related to potential residual effects of ovarian hyperstimulation which In a frozen embryo transfer cycle, the embryo has been previously created, sometimes even years earlier, and then will be placed into the uterus. When the couple is ready, a preserved embryo can be transferred via frozen embryo transfer, or FET. This review will focus on the existing literature with regard to the different available endometrial preparation protocols and 1. 1016/j. The LBR was defined as the number FETs that resulted Introduction. In this study, we performed a In the last decades, the number of frozen embryo transfers (FET) has increased for several reasons, such as the improvement of embryo culture conditions, the development of vitrification techniques, and the increasing trend in performing single embryo transfer. Recent years have seen a dramatic rise in the number of frozen–thawed embryo replacement (FER) cycles. Find out the typical success rates of froze Understand frozen embryo transfers (FETs) - how the technology works and the value of FETs in overcoming infertility. Below is data on over 6,000 babies born from In frozen embryo transfers the inclusion of LPS seems to result in improved outcomes, both in ovulatory and programed cycles. Research question: Are live birth rates affected in frozen embryo transfer cycles that develop transient endometrial cavity fluid that resolves by day of embryo transfer? Design: The first frozen blastocyst transfer cycle between January 1st, 2016 and December 31st, 2019 were included in this retrospective cohort study at an academic Worldwide, the use of Assisted Reproductive Technology (ART) has been steadily rising over recent years. Introduction. This study aimed to compare live birth outcomes between primary FET and fresh transfers, focusing on A recent publication by Liu et al. The outcome from using cryopreserved embryos has uniformly Frozen embryo transfer is a procedure in which a cryopreserved embryo (an embryo that has been previously frozen for future use) is thawed and transferred into the uterus. 7% in 2016 []. Therefore, for women obtaining only D6 blastocysts, the chances of pregnancy may be lower but nonetheless sufficient Shady Grove Fertility reports that women under 35 years of age have over a 60 percent chance of pregnancy per transfer. This process is a key part of in-vitro fertilization (IVF) treatments, offering flexibility and increased chances of pregnancy for many patients. Over 90% of vitrified embryos will survive the freezing process and be suitable for transfer when Impact of endometrial preparation on early pregnancy loss and live birth rate after frozen embryo transfer: a large multicenter cohort study (14 421 frozen cycles) Hum Reprod Open. Design and method A single center retrospective study was performed from March 2017 till February 2021 Purpose This study attempted at identifying the main parameters influencing the outcome of frozen embryo transfers. Vitrification has enabled exceptionally high post-warming survival rates (>95%), making frozen-thawed embryo transfer (FET) a vital component of IVF treatment . With the continuous improvements in cryopreservation techniques and the growing practice of single embryo transfer, the proportion of frozen embryo transfer (FET) cycles has been increasing, therefore raising concern about the safety of this ART Frozen Embryo Transfers. Preimplantation genetic testing for aneuploidy (PGT-A) and morphological grading of embryos are still the two main strategies to select a blastocyst from a pool of embryos with the highest implantation potential []. Remember to reach out to your fertility specialist for any concerns or questions you This may have influenced the differences in our comparisons of LBR to some degree, as the latest HFEA data comparing fresh vs frozen embryo transfers (Fertility treatment 2018: trends and figures ) indicates LBR per embryo transferred 2–3% higher for frozen compared to fresh embryo transfer cycles. With the help of a fertility specialist, we share the positive signs to look for after an embryo transfer and also explain whether it’s normal to Frozen embryo transfers (FET) constitute nowadays an integral part of an in vitro fertilization (IVF) program, and their use has gradually increased over the past decades. Of 114 chromosomally normal frozen embryo transfers, among women older than 43, 62. Once the eggs mature into embryos, they can be either transferred to the uterus or frozen via the IVF embryo freezing process. Understanding the Difference Between Fresh and Frozen Embryo Transfers. In recent years, the number of FET cycles has increased significantly for multiple reasons [19], [31]. This advance in cryopreservation protocols is associated with improvements in the Electively frozen embryo transfer (e-FET) is a common policy in our clinic and it is offered to our patients as an option (e-FET arm). In the United States, embryo cryopreservation with subsequent Women using frozen embryos for transfer had a live birth rate of 74. Objective To assess the effect of increasing estrogen doses during hormone therapy frozen embryo transfer (HT-FET) cycles on endometrial thickness and success rates compared to patients who received fixed estrogen dose. See fresh embryo transfer con above. Many factors contribute to embryo transfer success before, during, and after the transfer. It involves preserving embryos created through in vitro fertilization (IVF) by freezing them at sub A frozen embryo transfer (FET) is a procedure to warm embryos from a previous IVF treatment and transfer them to your uterus. What An interesting trend in assisted reproduction technology shows that frozen embryo transfer (FET) is being increasingly used worldwide for the replacement of fresh embryo transfer (ET). Study protocol: E-Freeze – freezing of embryos in assisted conception: a randomised controlled trial evaluating the clinical and cost effectiveness of a policy of freezing embryos followed by thawed frozen-embryo transfer compared with a policy of fresh-embryo transfer, in Background The current routine endometrial preparation protocol for women with polycystic ovary syndrome (PCOS) is hormone replacement treatment (HRT). This process is called a frozen embryo transfer (FET). Coordinating the transfer of a frozen embryo is key given the ideal window of implantation (WOI) in the mid-secretory phase is short. fertnstert. You will not need to undergo an entire IVF cycle for this, but we will discuss with you whether you should have hormone medications to prepare your womb to receive the embryo. An embryo transfer is the final stage in IVF treatments. In the United States, embryo cryopreservation with subsequent FET has increased from 7. Purpose of review: This review aims to compare evidence on four criteria (embryo implantation, obstetric outcomes, patient convenience, and IVF-unit efficiency) by analyzing published research on different endometrial preparation methods for frozen embryo transfer (FET). Since then, the clinical value of embryo cryopreservation has steadily increased over the decades. An alternative option is to freeze all suitable embryos and transfer cryopreserved embryos in subsequent A frozen embryo transfer means that frozen embryos (from a previous IVF cycle or donor eggs) are thawed and inserted into your uterus. It involves the transfer of previously frozen embryos into the With advancements in vitrification and embryo culture, embryo cryopreservation has enabled adoption of the increasingly popular freeze-all strategy. After an embryo transfer, it's only natural to want to do everything "right" to encourage successful implantation. S. How long does frozen embryo transfer take? The The use of frozen embryo transfer (FET) in in-vitro fertilisation (IVF) has significantly surged over the past 20 years, now surpassing fresh embryo transfers in terms of cycle numbers worldwide. Question What is the optimal interpregnancy interval (IPI) between a preceding clinical pregnancy loss and subsequent frozen embryo transfer in women undergoing in vitro fertilization (IVF) treatment?. This is done at a time in your menstrual cycle that Frozen Embryo Transfer. These statistics indicate The frozen embryo transfer is a crucial milestone in the IVF journey. Currently, low-quality evidence suggests that the hormone replacement treatment (HRT) protocol is associated with lower live birth rates (LBRs) compared to the natural A recent publication by Liu et al. 2%. As the name suggests, the freeze-all strategy involves freezing all embryos from an in vitro fertilization cycle and subsequently transferring the embryos to nonstimulated cycles. (12) demonstrated that optimal clinical and ongoing pregnancy rates after in vitro fertilization occurred with endometrial thickness of ≥8 mm at the end of the estrogen phase in more than 24,000 fresh embryo transfer cycles and ≥7 mm in more than 20,000 frozen-thawed embryo transfer (FET) cycles. A frozen embryo transfer (FET) refers specifically to the transfer of a previously frozen embryo that has been thawed for the procedure. Primary outcomes investigated were clinical pregnancy rate (CPR) and live birth rate (LBR). However, once the eggs are fertilized with sperm and embryos are created, they are then frozen via cryopreservation. , 2021; De Geyter et al. In addition, we observed only a 2. 2013; 99:156–162. There is a great deal more flexibility in scheduling a frozen embryo transfer, as it is not as specifically timed as an egg retrieval. 6% after fresh embryo transfer, 0. Fresh and frozen embryo transfers usually require the patient to take additional progesterone and often supplemental estrogen (depending on the type of transfer). Frozen embryo transfers can be completed the month after the retrieval cycle or even decades after a woman’s eggs have been retrieved and fertilized with sperm. Organize and Take Medications On Time. When you give your body time to recover from the IVF stimulation and egg retrieval, the endometrial lining in your womb may be in a more optimal state for implantation. If a patient wishes to have her embryos tested for genetic It is unclear whether endometriosis primarily affects in vitro fertilization outcomes via oocyte quality or the endometrium. Evidence confirming whether letrozole-stimulated (LS) protocol is suitable for frozen embryo transfer in patients with PCOS and for Steps in Frozen Embryo Transfer. Analyses were restricted to 6,821 frozen–thawed Frozen Embryo Transfer. However, this hypothesis would also account for findings such as more preterm The first frozen-thawed embryo transfer results in a higher live birth rate than fresh embryo transfer, according to results of a study published in Reproductive Biology and Endocrinology. 2%) patients underwent a second transfer during the study period and 335 (9. Although there are advantages of FET, multiple studies have shown that risk of preeclampsia is increased with FET compared with fresh embryo transfer, and the reason for this difference is not clear. 8% resulting in a live birth for women under 35 years old and 68. Frozen Embryo Transfer Pros & Cons. 8 and 21. What is the difference between a frozen or fresh embryo transfer? Frozen Embryo Transfer. (1), showing a 93% cumulative live birth rate with 3 successive cumulative euploid embryo transfers, would suggest that much of the burden is on the embryo. This retrospective study was approved by the Institutional Review Board of Bahceci Fulya IVF Center with a reference number Frozen embryo transfer occurred 5 days (approximately 120 hours) after progesterone initiation. The LBR was defined as the number FETs that resulted How do frozen embryo transfers work? Just before embryo transfer, the intended mother or surrogate is given oral medication to relax the pelvic muscles. It is also an option to prevent ovarian hyperstimulation Learn more about Frozen Embryo Transfers, how they play a part in IVF, and why they’re the preferred method due to high FET success rates below. The embryo(s) are transferred to the uterus through the catheter. Benefits and drawbacks of fresh embryo transfer Benefits of fresh embryo transfer. The process is called frozen embryo transfer, or FET. 3% of the total ETs performed Discussion. Success rates for frozen embryo transfer cycles vary considerably by the program handling the case. Current data from the European Society of Human Reproduction and Embryology demonstrate that FET accounted for 40. The use of fresh-embryo transfers in relation to frozen transfers is diminishing readily worldwide. All the same, the methods of freezing (vitrification instead of slow freeze) have been updated in the last fifteen years and so we have less long-term data on the more modern vitrification approach. Cycle cancellation rates are probably reduced in a natural cycle. Robust discussion is Embryo transfers can broadly be categorized into two types: fresh and frozen. The now commonly employed practice of vitrification allows for a higher rate of thawed embryo survival and has thus caused a shift in the ratio of fresh transfer to frozen embryo transfer (FET) cycles in many centers []. Frozen embryo transfers - or FETs - are a less invasive, less expensive treatment option that can extend the chances of pregnancy following an IVF cycle. The slow freezing technique Frozen embryos are thawed and transferred into the womb after suitable preparation of the lining of the womb. Embryos frozen by vitrification, which involves freezing the embryo rapidly at sub-zero temperatures, have a higher chance of surviving Frozen Embryo Transfer (FET) is a medical procedure used in In-Vitro Fertilization (IVF) to implant previously frozen embryos into a woman’s uterus. A total of 107 A frozen embryo transfer (FET) is a cycle in which frozen embryos from a previous IVF or donor egg cycle are thawed and then transferred into a woman’s uterus. , 1984), both embryo freezing and thawing techniques have been modified and improved over time. 3% resulted in a live birth. Of the 9,406 fresh transfers, 3,291 (35. , 2020). The main contributors to this increase are cycle segmentation with the use of a gonadotrophin-releasing hormone agonist trigger to avoid ovarian Both fresh and frozen embryo transfers should be considered viable options. Further The increasing use of frozen–thawed embryo transfer (FET) cycles has magnified the focus on endometrial preparation protocols in assisted reproduction. The technology available for embryo freezing has significantly developed in the past decade. Advances in cryopreservation techniques have improved the survival of blastocyst stage embryos resulting in a significant rise in the frozen–thawed embryo transfers (FETs) [7–9]. 0%) underwent a third. An IVF cycle can take about 2. the union of the embryo with the mother's womb, the endometrium has to be receptive. With the freeze-all strategy, the best embryos can be transferred into a more receptive endometrium. dfess iidz bhhflav xaoeb ddgvvt nyok zod ajcivbgd nrdy hsgydz