Endometrial preparation for frozen embryo transfer
Endometrial preparation for frozen embryo transfer. Rev. Design Retrospective cohort study. Google Jul 8, 2021 · PubMed and EMBASE databases were searched for studies that included the keywords (endometrial preparation, frozen embryo transfer, oocyte donation, egg donation, cryo-thawed, natural cycle, frozen embryo transfer, modified natural cycle embryo transfer, artificial frozen cycle, artificial frozen cycle with gonadotropin suppression) and MeSH Comparison of stimulated versus modified natural cycles for endometrial preparation prior to frozen embryo transfer: a randomized controlled trial Reprod Biomed Online . Purpose: To compare the effects of different endometrial preparation protocols for frozen-thawed embryo transfer (FET) cycles and present treatment hierarchy. Aug 26, 2024 · Preparing for FET: Understanding the Initial Steps. Pregnancy rates following cryopreserved embryo transfer cycles are usually lower than fresh embryo transfer cycles. Methods A retrospective study on 2080 FET cycles including patients Jan 26, 2018 · Relationship between endometrial thickness parameters (endometrial thickness on oocyte retrieval day and endometrial thickness on starting day of progesterone supplementation in frozen-thawed blastocyst embryo transfer (FET) cycles), maternal age (maternal age on oocyte retrieval day and during frozen-thawed blastocyst embryo transfer cycles Jul 31, 2014 · Purpose To assess which is the optimal protocol in terms of endometrial preparation prior to frozen-thawed embryo transfer (FET) in women with polycystic ovarian syndrome (PCOS) and to explore the effect in stimulated cycle with the addition of vaginal 17-β oestradiol. 007. Nov 1, 2022 · In a frozen embryo transfer (FET) cycle, the endometrium should be developed optimally before embryo transfer. 2020. Your journey begins with an initial consultation where your healthcare team assesses your uterine and overall health. 2022. Sev … Dec 10, 2022 · 1. This Views and Reviews article focuses … Jan 30, 2023 · In the programmed cycle, spontaneous ovulation is inhibited, and exogenous estrogen and progesterone are provided for the preparation of endometrium . A total of 16,867 frozen-thawed embryo transfer (FET) cycles were categorized into three groups based on endometrial preparation protocols: Natural cycle (NC n = 3893), artificial cycles (AC, n = 11456) and AC with GnRH-a pretreatment (AC+GnRH-a, n = 1518). Patient(s) One thousand four hundred thirteen patients with endometriosis who underwent oocyte aspiration from 2015 to 2020 and frozen embryo transfer from 2016 to 2020 and received Nov 1, 2017 · Study question: What is the optimal endometrial preparation protocol for a frozen embryo transfer (FET)? Summary answer: Although the optimal endometrial preparation protocol for FET needs further research and is yet to be determined, we propose a standardized timing strategy based on the current available evidence which could assist in the harmonization and comparability of clinic practice Jan 9, 2023 · Objective To determine the optimal endometrial preparation protocol for a frozen embryo transfer in patients with endometriosis. Forty-one studies involving 43,021 participants were analyzed using meta-analysis Dec 29, 2023 · I NTRODUCTION. 06. 1002/14651858. Primary outcomes investigated Jul 12, 2019 · Kazuki Saito, Akira Kuwahara, Tomonori Ishikawa, Naho Morisaki, Mami Miyado, Kenji Miyado, Maki Fukami, Naoyuki Miyasaka, Osamu Ishihara, Minoru Irahara, Hidekazu Saito, Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus, Human Reproduction, Volume 34 Sep 20, 2021 · Keywords: frozen-thawed embryo transfer, endometrial preparation, endometrial receptivity, embryo implantation, in vitro fertilization, down regulation ovulation induction Introduction With the application of vitrification techniques and widespread ongoing adoption of freeze-all strategy, the number of FET cycles has dramatically increased ( 1 ). (Fertil Steril 2016;105: 867–72. 425 - 429 , 10. However, transfer of excess embryos in frozen cycles increases the cumulative pregnancy rates and decreases the costs. Jun 8, 2023 · Over the past decade, the application of frozen-thawed embryo transfer treatment cycles has increased substantially. Citation: Xu J, Li S-Z, Yin M-N, Liang P-L, Li P and Sun L (2021) Endometrial Preparation for Frozen–Thawed Embryo Transfer With or Without Pretreatment With GnRH Agonist: A Randomized Controlled Trial at Two Centers Purpose: The purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles. Systematic review with meta-analysis was performed by electronic searching of MEDLINE, the Cochrane Nov 1, 2017 · Study question: What is the optimal endometrial preparation protocol for a frozen embryo transfer (FET)? Summary answer: Although the optimal endometrial preparation protocol for FET needs further research and is yet to be determined, we propose a standardized timing strategy based on the current available evidence which could assist in the harmonization and comparability of clinic practice Jan 9, 2023 · Objective To determine the optimal endometrial preparation protocol for a frozen embryo transfer in patients with endometriosis. Hormone replacement therapy and the natural cycle are two popular methods for preparing the endometrium. doi: 10. Reliable data are essential Sep 19, 2021 · Background: In recent years frozen-thawed embryo transfer (FET) has played an increasingly important role in ART, but there is limited consensus on the most effective method of endometrial preparation (EP) for FET. In frozen embryo transfers, low-quality evidence showed that clinical pregnancy rates may be improved in a stimulated cycle compare … Jan 22, 2020 · The objective was to compare the endometrial thickness (ET) in a frozen embryo transfer (FET) cycle between transdermal and vaginal estrogen. 5-year period in the Fertility Unit at a University Hospital. Optimization of endometrial preparation protocols before frozen embryo transfer is mandatory to further improve pregnancy outcomes. INTRODUCTION. While there are many benefits to delayed frozen embryo transfer, certain adverse perinatal outcomes are noted to be more common in these transfers when compared to fresh transfers, specifically hypertensive disorders of pregnancy. Increasing numbers of elective single ETs are also resulting in more frozen embryos (blastocysts) available for subsequent frozen ET cycles. One of the most challenging issues in frozen-thawed embryo transfer (FET) cycles is a selection of an appropriate endometrial preparation method that provides the most endometrial receptivity and synchronization between embryonic and endometrial development. Simon C, Domínguez F, Valbuena D, Pellicer A. Correlation between different endometrial preparation protocols and pregnancy outcome of frozen embryo transfer in patients with polycystic ovary syndrome: a retrospective study Gynecol Endocrinol . ) Key Words: Frozen-thawed embryo transfer, endometrium, window of receptivity, molecular markers of Jun 21, 2024 · The endometrial receptivity and the coordination between endometrium and embryo development are the key points for implantation [1, 2]. Aug 7, 2022 · Two types of endometrial preparation protocols are used for frozen embryo transfers in current practice: hormone replacement and the natural cycle. ) Key Words: Window of implantation, frozen embryo transfer, endometrial preparation Background: Sildenafil citrate may increase endometrial thickness and affect the outcome of frozen-thawed embryo transfer cycles. The investigators review the various types of endometrial preparation including the use of the natural, modified natural, stimulated, and programmed cycles. 0% of ART pregnancies born worldwide in 2012. 2016 by American Society for Reproductive Medicine. 2019;34:1567–75. org. Feb 1, 2020 · This Views and Reviews article focuses on our current knowledge of the biology of endometrial receptivity and on the role of both invasive (endometrial biopsy) and noninvasive (ultrasound) assessment in successful endometrial preparation for frozen-thawed embryo transfer. 2022 Dec;45(6):1182-1187. Feb 15, 2022 · Impact of endometrial preparation on early pregnancy loss and live birth rate after frozen embryo transfer: a large multicenter cohort study (14 421 frozen cycles) Hum Reprod Open . Frozen embryo transfers Oct 17, 2021 · Keywords: frozen embryo transfer, endometrial preparation, hormone replacement treatment, GnRH agonist, reproductive outcomes. rbmo. Methods: We analyzed totally 1,230 cycles of patients that underwent FET from October 2010 to September 2012. Cochrane database Syst. The role of estrogen in uterine receptivity and blastocyst implantation. Kawwass1 Abstract The use of frozen embryo transfer in assisted reproductive technology (ART) has steadily increased since develop-ment in the early 1980’s. Apr 28, 2017 · Impact of Endometrial Preparation Protocols for Frozen Embryo Transfer on Live Birth Rates Rambam Maimonides Med J . Various factors, including treatment protocols, can influence the outcomes of frozen embryo transfers (FETs). Cochrane Database Syst Rev (2020) 10 :CD006359. Jun 8, 2023 · Endometrial preparation is a crucial stage in FET cycles, and several protocols are available, including true natural cycle with spontaneous ovulation, modified natural cycle with human chorionic gonadotrophin (hCG) to trigger ovulation, hormone replacement therapy (HRT) cycle with or without gonadotropin-releasing hormone agonist (GnRH-a) downr Jul 9, 2021 · Endometrium preparation protocols for frozen embryo transfer (FET). a ∙ Elena H. Before your frozen embryo transfer (FET), an essential phase involves thorough preparation. However, studies have found that HRT may increase the risk of hypertensive disorders of pregnancy and some obstetric complications. Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes. In a frozen embryo transfer (FET) cycle, the endometrium should be developed optimally before embryo transfer. While there are many benefits to delayed frozen embryo transfer, certain adverse perinatal outcomes are noted to be more common in these transfers when compared t … Oct 14, 2022 · Introduction. Since the first successful frozen-thawed embryo transfer (FET) was reported in 1983(), embryo cryopreservation has become an important issue. This review will focus on the existing literature with regard to the different available endometrial preparation protocols and their impact on pregnancy outcomes. Our secondary objectives were to compare the patient satisfaction and the pregnancy outcomes. Oct 28, 2020 · Thus, the endometrial preparation and profile is one of the main variables to be evaluated in women undergoing an embryo transfer procedure using donated oocytes, and also in frozen‐thawed embryo transfers. Frozen‐thawed embryo transfer (FET) is an important procedure in assisted reproductive technology (ART). Endometrial receptivity appears to be as important as chromosomal normality in determining embryo implantation and pregnancy outcome, because the ongoing pregnancy rate with transfer of preimplantation genetic testing for aneuploidy euploid blastocysts is ∼50%. Aug 29, 2023 · Glujovsky D, Pesce R, Sueldo C, Quinteiro Retamar AM, Hart RJ, Ciapponi A. 1016/j. 2217260. Endometrial preparation in the natural cycle reportedly increases the chances of live birth and decreases early pregnancy loss compared with that in the hormone replacement cycle. Oct 28, 2020 · With artificial endometrial preparation (programmed cycle) for women undergoing embryo transfer with frozen embryos or the transfer of fresh embryos derived from donated oocytes the aim is to stimulate the growth of the endometrium in a similar fashion to the natural cycle, by the sequential administration of oestrogen and progestogen. 2024. Methods: We performed a retrospective study of 1926 FET cycles over a 3. Optimal endometrial preparation and identification of the receptive window for ET in frozen ET cycles thus assumes utmost importance for insuring the best frozen ET outcomes. The use of oral dydrogesterone may be a more patient-friendly approach to endometrial preparation in frozen-thawed embryo transfer cycles, avoiding undesirable side effects and discomfort resulting from vaginal administration, while also providing similar reproductive results. Prospective monocentric cohort study between 01/2017 and 12/2017 … What is a frozen embryo transfer cycle? A frozen embryo transfer cycle is a process to help you become pregnant. Introduction. [See original video in Spanish]. Optimal endometrial preparation for frozen embryo transfer cycles: window of implantation and progesterone support. 10 , 006359 (2020). Nov 6, 2017 · The purpose of this study was to determine the effect of stimulated and artificial endometrial preparation protocols on reproductive outcomes in frozen embryo transfer (FET) cycles. This single-centre, large-sample retrospective trial was designed to Sep 1, 2016 · Frozen-thawed (FT) embryo transfer is a procedure used for the storage and transfer of excess embryos obtained during in vitro fertilization- intracytoplasmic sperm injection cycles. Nov 14, 2023 · Endometrial compaction and serum progesterone measurements at the day of embryo transfer cannot predict pregnancy outcomes in frozen-thaw embryo transfer cycles. The natural cycle protocol was the better endometrial preparation protocol for f … Jun 28, 2021 · Glujovsky, D. [Google Scholar] Sep 5, 2023 · There was inconsistency in optimal endometrial preparation protocol for frozen-thawed embryo transfer (FET) in patients with endometriosis. 2023 Oct 10;39(1):2269269. et al. In the current systematic review, we aim to compare different FET protocols in terms of reproductive, obstetric and maternal outcomes. You will be given Sep 22, 2022 · Saito K, Kuwahara A, Ishikawa T, Morisaki N, Miyado M, Miyado K, Fukami M, Miyasaka N, Ishihara O, Irahara M, Saito H. We conducted this study to investigate the effect of different endometrial preparation protocols on the pregnancy Aug 23, 2018 · The ability to synchronize oocyte donor and recipient cycles has expanded our understanding of endometrial preparation and embryo-endometrial synchronicity, providing knowledge that can be applied to other treatment protocols such as frozen embryo transfer . Primary outcomes investigated were clinical pregnancy rate (CPR) and live birth rate (LBR). Apr 23, 2021 · Background Low serum progesterone on the day of frozen embryo transfer (FET) is associated with diminished pregnancy rates in artificial endometrium preparation cycles, but there is no consensus on whether strengthened luteal phase support (LPS) benefits patients with low progesterone on the FET day in artificial cycles. Citation: Xu Y, Song J-Y and Sun Z-G (2024) Editorial: Exploring the optimal endometrial preparation protocol for frozen-thawed embryo transfer. pub3 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] The use of frozen embryo transfer cycles has exponentially increased in the last few years. Jan 25, 2016 · Optimal endometrial preparation for frozen embryo transfer cycles: window of implantation and progesterone support. (Fertil Steril 2020;113:248–51. [8] Limited evidence also supports removal of cervical mucus before transfer. 2019 by American Society for Reproductive Medicine. More spe- Mar 8, 2022 · Robert F, Casper MD, Elena H, Yanushpolsky MD. The opportunity for frozen embryo transfer is highly relevant to the thickness of the endometrium and sex hormone levels. As the use of frozen embryo transfer (FET) continues to rise, the optimal endometrial preparation protocol has yet to be determined. 1007/s10815-017-1078-0 Live birth rates after different endometrial preparation methods in frozen cleavage-stage embryo transfer cycles: a randomized controlled trial Arch Gynecol Obstet . 15:1377488. Setting Tertiary care academic medical center. The objective of this study was to compare the implantation rate, pregnancy rate and endometrial thickness of frozen-thawed embryo transfers using endometrial preparation with either an artificial cycle or stimulated cycle. Oct 27, 2023 · Background The current routine endometrial preparation protocol for women with polycystic ovary syndrome (PCOS) is hormone replacement treatment (HRT). Apr 25, 2015 · This document discusses different methods for endometrial preparation in frozen embryo transfer (FET) cycles. 2269269. This is done at a time in your menstrual cycle that best supports a pregnancy. FET uses embryos (fertilized eggs) that have been frozen. It describes natural cycle FET, which can be done through a true natural cycle or modified natural cycle with an HCG trigger. Robert F. of both invasive (endometrial biopsy) and noninvasive (ultrasound) assessment in successful endometrial preparation for frozen-thawed embryo transfer. 1 The synchronisation of embryo and endometrium development plays an important role in implantation. Apr 28, 2017 · INTRODUCTION. Materials and methods: This randomized interventional study was conducted on 100 women who underwent a FTET that were randomly assigned to receive GnRH agonist (buserelin) in the luteal phase or no receive this medication. J Assist Reprod Genet 2018; 35:425–429. 2 Endometrial preparation is of utmost importance for FET Oct 18, 2021 · Glujovsky D, Pesce R, Sueldo C, Quinteiro Retamar AM, Hart RJ, Ciapponi A. Casper, M. Cochrane Database Syst Rev (2020) 10 :Cd006359. Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer: the risk of early pregnancy loss in frozen embryo transfer cycles. This was a prospective randomized trial at a single academic IVF centre. With the freeze-all strategy, the best embryos can be transferred into a more receptive endometrium. In recent years, improvements in laboratory conditions and limitations on the number of embryos to be transferred hav … Nov 20, 2020 · Background: Considering that clinical trial studies are limited in polycystic ovary syndrome (PCOS) patients, and there is no consensus on an optimum endometrial preparation protocol for frozen embryo transfer (FET), the present study was designed as a randomized clinical trial to compare the reproductive outcomes following stimulated cycles with letrozole plus human menopausal gonadotropin A scientific review in 2013 came to the conclusion that it is not possible to identify one method of endometrium preparation in frozen embryo transfer as being more effective than another. Yanushpolsky, M. In other words, it can happen as soon as the next cycle after your egg retrieval or several months (or years) later. Letrozole is a new first-line ovulation induction drug for PCOS and can Purpose: The aim of this study was to compare the outcomes of three endometrial preparation methods prior to frozen embryo transfer (FET): Natural cycle (NC), modified natural cycle (mNC), and programmed/artificial cycle (AC) protocols. Open in a separate window. 1080/09513590. This Views and Reviews article focuses on our current knowledge of the biology of endometrial receptivity and on the role of both Jan 30, 2022 · Purpose The aim of this study was to compare the outcomes of three endometrial preparation methods prior to frozen embryo transfer (FET): Natural cycle (NC), modified natural cycle (mNC), and programmed/artificial cycle (AC) protocols. 2023 Dec;39(1):2217260. 2020 Apr;40(4):518-524. Patient(s) One thousand four hundred thirteen patients with endometriosis who underwent oocyte aspiration from 2015 to 2020 and frozen embryo transfer from 2016 to 2020 and received Sep 8, 2017 · What is the optimal endometrial preparation protocol for a frozen embryo transfer (FET)? SUMMARY ANSWER Although the optimal endometrial preparation protocol for FET needs further research and is yet to be determined, we propose a standardized timing strategy based on the current available evidence which could assist in the harmonization and Aug 1, 2019 · Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus Hum Reprod . 2019 Apr;299(4):1185-1191. 1007/s00404-019-05062-7. Comparison of different endometrial preparation protocols on frozen embryo transfer pregnancy outcome in patients with normal ovulation Reprod Biomed Online . However, the issue of how to prepare the endometrium before frozen-thawed embryo transfer (FET) to improve pregnancy outcomes remains uncertain, especially for polycystic ovary syndrome (PCOS) women [3,4,5]. While programmed cycles have traditionally been used, natural cycle FET (NC-FET) has become increasingly common in light of data suggesting that NC-FET cycles are equally effective in achieving pregnancy and live birth[1,2,3,4,5] while reducing The optimal preparation of the uterine lining to maximize implantation and optimize obstetric outcomes has evolved since the 1984 report, published in Nature, of successful exogenous hormone endometrial preparation in a young woman with premature ovarian failure, who subsequently delivered a healthy infant because of a donor oocyte in vitro fertilization (IVF) cycle (1). 5041/RMMJ. Nov 1, 2022 · The use of frozen embryo transfer cycles has exponentially increased in the last few years. Apr 7, 2021 · To compare the effects of different endometrial preparation protocols for frozen–thawed embryo transfer (FET) cycles and present treatment hierarchy. Apr 7, 2021 · Frozen–thawed embryo transfer (FET) is a widely accepted procedure used for the storage and transfer of excess embryos produced in fresh in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) cycles. To The impact of endometrial preparation for frozen embryo transfer on maternal and neonatal outcomes: a review Jacqueline C. Dec 30, 2019 · This was a prospective trial comparing the outcome of endometrial preparation in frozen embryos transfer cycle by letrozole and hormone replacement. Endometrial preparation methods for frozen-thawed embryo transfer are associated with altered risks of hypertensive disorders of pregnancy, placenta accreta, and gestational diabetes mellitus. Robert F, Casper MD, Elena H, Yanushpolsky MD. Gorka Barrenetxea and Edurne Martínez Sanz. It is also an option to prevent ovarian hyperstimulation syndrome and to perform preimplantation genetic testing (PGT Feb 15, 2022 · Hatoum I, Bellon L, Swierkowski N, Ouazana M, Bouba S, Fathallah K, Paillusson B, Bailly M, Boitrelle F, Alter L et al. 5%) were excluded due to non-development of the dominant follicle and endometrial growth Jan 20, 2010 · Endometrial preparation for women undergoing embryo transfer with frozen embryos or embryos derived from donor oocytes Review Demián Glujovsky, Romina Pesce, Carlos Sueldo, Andrea Marta Quinteiro Retamar, Roger J Hart, Agustín Ciapponi. Oct 28, 2020 · There is insufficient evidence on the use of any particular intervention for endometrial preparation in women undergoing fresh donor cycles and frozen embryo transfers. 40 patients were given estradiol by a step up method with menstruation to prepare the endometrium, and the other 40 were given sildenafil citrate tablets (50 mg) daily in addition to the Introduction Hormone replacement treatment (HRT) is the most commonly used endometrial preparation protocol for frozen embryo transfer (FET) in patients with polycystic ovary syndrome (PCOS). pub3 [ PMC free article ] [ PubMed ] [ CrossRef ] [ Google Scholar ] Sep 5, 2023 · There was inconsistency in optimal endometrial preparation protocol for frozen-thawed embryo transfer (FET) in patients with endometriosis. Hormone replacement therapy is now used at the discretion of the doctors becau … Oct 10, 2023 · The natural cycle protocol of endometrial preparation for frozen embryo transfer decreases the miscarriage rate in women with recurrent pregnancy loss Gynecol Endocrinol . Hum Reprod. Jan 22, 2020 · The objective was to compare the endometrial thickness (ET) in a frozen embryo transfer (FET) cycle between transdermal and vaginal estrogen. 01. Feb 21, 2024 · Keywords: frozen embryo transfer, natural cycle, hormone replacement cycle, corpus luteum (CL), pregnancy outcomes. Seven hundred and thirteen cycles of patients Materials and Methods: This randomized controlled trial was conducted on 80 patients who had an antecedent of poor endometrial response and frozen embryos. According to a report by the International Committee for Monitoring Assisted Reproductive Technologies, 1 FET pregnancies accounted for 27. This review will focus on the existing literature with regard to the differe … Given the unique therapeutic effects, we were interested in determining whether pretreatment with He-Ne laser irradiation prior to frozen-thawed embryo transfer (FET) would improve the microcirculation and cause the release of growth factors and cytokines, thus improving endometrial receptivity and the clinical pregnancy rates. [9] May 6, 2021 · This retrospective cohort study aimed to explore the optimal endometrial preparation protocols among different maternal age groups. Feb 13, 2021 · 1. Letrozole is rarely used in frozen embryo cycles. The first successful pregnancy from a frozen-thawed embryo transfer (FET) was reported in 1983. A systematic review of English language studies published before 1 September 2022, was conducted, excluding conference papers and preprints. b eyanushpolsky@partners. 5-year Jul 29, 2022 · A frozen embryo transfer can be done at any point in the future if you have already undergone an in vitro fertilization (IVF) cycle that generated usable embryos. In the letrozole group, 82 women were followed, the analysis was limited to 80 women, since 2 of them (2. 2017 Apr 28;8(2):e0020. We performed a retrospective study of 1926 FET cycles over a 3. 1377488 Mar 29, 2024 · This study investigates the effect of GnRHa pretreatment on pregnancy outcomes in artificial endometrial preparation for frozen–thawed embryo transfer (AC-FET) cycles. Lee1*, Martina L. Frozen-thawed embryo transfer (FET) has been widely used in vitro fertilisation (IVF) because it prevents ovarian hyperstimulation syndrome, facilitates single embryo transfer and improves fertility and pregnancy outcomes. Dec 17, 2012 · HCG may have systemic and local effects on the embryo-endometrial microenvironment . 2023. Prospective monocentric Jun 19, 2020 · Introduction. Endometrial Preparation for Women Undergoing Embryo Transfer With Frozen Embryos or Embryos Derived From Donor Oocytes. Methods This was a Nov 30, 2022 · Original video: Transferencia de embriones congelados (Frozen Embryo Transfer), by Dr. cd006359. We conducted this study to investigate the effect of different endometrial preparation protocols on the pregnancy outcomes in patients with endometriosis undergoing FET cycles, and determine the optimal number of GnRHa injections in GnRHa-HRT protocols. CD006359. Reliable data are essential for defining the optimal endometrial preparation protocols with ac-curate determination of the implantation window in frozen ET cycles. Our secondary objectives were to compare the patient Sep 30, 2020 · The natural cycle protocol yielded thicker endometria, a higher implantation rate and a lower risk of caesarean section than the hormone replacement therapy protocol in the transfer of two cleavage-stage frozen embryos. Purpose: To evaluate the clinical efficacy of letrozole on ovulation induction and hormone replacement therapy (HRT) during endometrial preparation for frozen-thawed embryo transfer (FET). 1 More than three decades have passed, and significant changes have been introduced into our clinical practice. gov and Google Scholar up to Dec 26, 2020. Abstract. Oct 1, 2020 · Disparities in reproductive outcomes according to the endometrial preparation protocol in frozen embryo transfer: the risk of early pregnancy loss in frozen embryo transfer cycles J Assist Reprod Genet , 35 ( 3 ) ( 2018 ) , pp. 10297. In order to prepare the endometrium, several protocols have been suggested: natural cycles, where detecting the luteinising hormone (LH) surge, and, therefore, the ovulation, defines the timing of the transfer; modified natural cycles, where ovulation is triggered by the administration Objective: To evaluate the efficacy of endometrial preparation by exogenous steroids, with and without pretreatment by the use of GnRH agonist. Evidence confirming whether letrozole-stimulated (LS) protocol is suitable for frozen embryo transfer in patients with PCOS and for whom is suitable remains lacking. The natural cycle protocol was the better endometrial preparation protocol for frozen embryo transfer. 1093/hropen/hoac007. Inspired by significantly higher implantation rate and clinical pregnancy rate of the depot GnRH-a protocol, we proposed a novel EP Jun 8, 2023 · Currently, there is increasing interest in how the method of endometrial preparation may influence frozen embryo transfer outcomes specifically, especially when it comes to details such as different types of ovulation monitoring and different luteal support in natural cycles, and the ideal exogenous hormone administration route as well as the Feb 28, 2022 · The use of frozen embryo transfer in assisted reproductive technology (ART) has steadily increased since development in the early 1980's. Objective: The aim of this study was to estimate the effect of sildenafil citrate on ultrasonographic endometrial thickness and pattern and to investigate the estrogen level on the day of progesterone administration, the implantation rate and chemical pregnancy rate May 20, 2024 · Objective: The aim of this study was to compare endometrial thickness with the use of transdermal estrogen (gel) versus oral estrogen (pills) for endometrial preparation in the frozen embryo transfer cycle and serum estrogen concentrations during the preparation cycle, side effects, and chemical and clinical pregnancy rates. Front. Sep 30, 2020 · The natural cycle protocol yielded thicker endometria, a higher implantation rate and a lower risk of caesarean section than the hormone replacement therapy protocol in the transfer of two cleavage-stage frozen embryos. During the FET cycle, your embryos are thawed and placed into your uterus. Download PDF. Methods: Systematic review with meta-analysis was performed by electronic searching of MEDLINE, the Cochrane Library, Embase, ClinicalTrials. Endocrinol. 3389/fendo. Int J Res Pharm Sci (2021) 12 (1):407–15. D. Badell2 and Jennifer F. Fertil Steril 2016;105:867–72. Early reports Jan 30, 2022 · The aim of this study was to compare the outcomes of three endometrial preparation methods prior to frozen embryo transfer (FET): Natural cycle (NC), modified natural cycle (mNC), and programmed/artificial cycle (AC) protocols. Jun 16, 2023 · Frozen-thawed embryo transfer (FET) has become a promising approach in assisted reproductive technique cycles in recent years due to cryopreservation technique improvements [1]. 026. FET is used as a complementary treatment with stimulated in vitro fertilization (IVF) cycles in patients with infertility and has attracted increasing attention worldwide (). 2022 Feb 15;2022(2):hoac007. Methods Five hundred and seventy-six patients with PCOS were prepared for FET using artificial cycle induced with oestradiol Feb 28, 2022 · The use of frozen embryo transfer in assisted reproductive technology (ART) has steadily increased since development in the early 1980’s. pmbrpafcsydnjlsyqcpteqixymoktgdagobmchztkpskjjhdhzibwz